Tuesday, March 13, 2012

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Monday, March 12, 2012

Re-Financing with Bad Credit

A long time ago, it would have been very hard for those with a bad credit score to obtain a mortgage loan from the get go. However, today there are numerous loan options available and for that reason many ways for creditors to protect themselves that joggers with bad credit are unable to only find a appropriate mortgage but can likewise find appealing re-financing things to do in maui selections as well.

Those with low credit score should carefully consider if re-financing is ideal for them at the present time but the process is just not much different for them because it is for those with a favorable credit record. Those with bad credit who want to learn more about re-financing should seek the advice of a mortgage advisor who seem to specializes in mortgages for all those with bad credit. As well as the homeowner should meticulously evaluate their credit ratings and whether or not there are improved. Finally this homeowner should review their options meticulously to ensure they are making perfect decision.

Consult a mortgage loan Advisor

Consulting with a mortgage advisor is recommended for all those with poor credit. These kinds of homeowners may be accustomed to the process of re-financing but their things to do in melbourne condition warrants consulting with a place expert. This is important want . mortgage advisor who seem to specializes in obtaining mortgage loans and re-financing for those having bad credit will likely be extremely knowledgeable about the types of available choices to the homeowners.

When consulting with the property finance loan advisor, the homeowners should be completely straightforward about their financial situation and should provide the expert with the information he would need to assist them locating an ideal re-financing agreement. Getting completely candid can be very helpful in enabling this mortgage advisor that can help the things to do in phoenix homeowner from the best way possible.

Think about Whether or Not Your Credit history has Improved

Property owners with bad credit ought to carefully consider whether or not their credit has improved upon since the original property finance loan was secured. Property owners who have documented proof past credit scores may compare these standing to current prices. Each citizen is definitely entitled to one free credit report per year from each major credit reporting organizations. Homeowners can obtain most of these reports for use when making comparisons to the earlier credit scores. Imperfections for the credit report such as bankruptcies, delinquent or forgotten payments and other transgressions don?t stay on the credit report.

These kinds of blemishes are often wiped out from the credit report following a certain period of time. The time the transgression is still on the report is definitely proportional to the severity of this offense. For example a personal bankruptcy will remain on the credit reports for significantly more than a late payment. With examining the credit report, homeowners should consider the entire credit score but need to note whether or not earlier offenses are being wiped out from the credit report in due time.

Evaluate Re-Financing Options Meticulously

Once a homeowner provides tentatively made a decision to re-finance the property finance loan, it is time to start thinking about the many options that are available to your homeowner during the process associated with re-financing. Most homeowners mistakenly consider one factor with the re-financing process they have absolutely no control over is the apr. While this rate is basically dependent on the homeowners credit score, even include those with poor credit have the ability to decrease their interest rate by getting point. A point is normally equally to 1% with the total loan amount and can translate to a associated with a percentage point for the interest rate. When figuring out whether or not to purchase factors, the homeowner ought to carefully consider the amount of time may well take the homeowner to extract the cost of purchasing the factors. This will help to determine if it is worthwhile to order one or more points as soon as re-financing.

Homeowners will also have selections in terms of the type of loan they will choose when re-financing. Typical options include set rate mortgages, adjustable rate mortgages (Forearms) and hybrid mortgage loans. The interest rate is still constant with a set rate mortgage, adjusts which has an ARM and is preset for a period of time and adjustable for the remainder of the financial loan period with a a mix of both loan.

Source: http://www.foodcontentalerts.info/re-financing-with-bad-credit

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Sunday, March 11, 2012

Dominique Strauss-Kahn flees student protesters

By msnbc.com staff and news services

LONDON -- Former International Monetary Fund chief Dominique Strauss-Kahn was bundled into the back of a police car to escape protesters after a speaking engagement at Britain's Cambridge University on Friday that angered women's rights activists.

About 150 demonstrators, waving banners and chanting "2, 4, 6, 8, no more violence, no more rape" had circled the Cambridge Union Society where Strauss-Kahn delivered a speech on globalization and the Eurozone to a select group of students.


As the French economist left, the angry crowd, shouting references to New York hotel maid Nafissatou Diallo who accused him of sexual assault, tried to scale barricades guarded by police and security officers set up to protect him.

Placards were thrown at the car and protesters scuffled with officers as he was whisked away.

"I don't think he should have been invited here to speak to students," student Morgan Wild, 23, told Reuters. "I think it's part of a crass PR campaign to rehabilitate his reputation and we shouldn't be taken for fools."

Strauss-Kahn calls sexual encounter with maid a 'moral failing'

"It's got nothing to do with freedom of speech," said student Francesca Williams, 21. "They're inviting a man who hates women. I don't think DSK should be given the privilege of speaking in front of a private audience."

Cambridgeshire Police said a 19-year-old man was arrested for assaulting a police officer and a woman, 22, was detained for a breach of the peace. Two others were arrested on Friday morning after banners were plastered all over the Union Society building.

The Cambridge News website displayed photos showing its walls defaced with messages including "DSK GO AWAY" and "WOMEN DESERVE BETTER."

'Flabbergasted'
There was tight security inside the venue with the gray-haired Strauss-Kahn flanked by four burly men during his speech and 25 guards brought in for the occasion.

But even within the historic 19th century building, where politicians such as British wartime leader Winston Churchill have addressed students, he was unable to escape controversy.

One student asked him to explain vaginal bruising suffered by Nafissatou Diallo, the maid behind the sexual assault allegations who is now pursuing civil claims against Strauss-Kahn in New York.

"The reality is that I spent a week in prison. There hasn't been a prosecution," he replied to a rapt audience listening over the faint shouts and sirens heard from outside.

Diallo's lawyer, Douglas Wigdor, spoke to about 100 Cambridge students and journalists on her behalf at a rival event earlier Friday.

According to the Guardian newspaper, Wigdor said he was "flabbergasted" at the invitation. He called it "an affront to all victims of sexual crimes."

"The history of Cambridge and the history of the union are now interspersed with Strauss-Kahn. I don't blame Strauss-Kahn. I blame the union," he said.

A statement posted Friday on the Cambridge union's website said the invitation was made well before Strauss-Kahn's controversial departure from the IMF. His experience in French politics mean that he was "exceptionally well qualified" to speak on the financial crisis and the French presidential election, it said.

Some of those attending the speech, many of them economics or politics students, agreed. They said they wanted to hear about Strauss-Kahn's experiences in the IMF and politics, not his personal life.

"This is a forum for free speech," said politics student Milad Matin, 21. "It's not a value judgement. I'm not endorsing rape by watching him speak."

Strauss-Kahn held in French prostitution probe

Strauss-Kahn has mostly kept a low profile since New York prosecutors dismissed charges of attempted rape and sexual assault against him in August, based on concerns about Diallo's credibility. But in recent months he has rejoined the international speech circuit.

Though the criminal case is over, the first civil court hearing over Diallo's claims is scheduled for March 28.

Video surveillance footage from the New York City hotel where former IMF chief Dominique Strauss-Kahn was accused of sexually assaulting a maid is raising new questions in the case. NBC's Michael Isikoff reports.

Strauss-Kahn was also held for two days in January in a police station in the northern French city of Lille, where investigators questioned him about allegations that a prostitution ring organized by his business acquaintances provided women for clients of Lille's Carlton Hotel.

Police want to establish whether Strauss-Kahn knew that women at parties he attended in Lille, Paris and Washington were prostitutes. His lawyer has said Strauss-Kahn had no reason to think so.

More from msnbc.com and NBC News:

Follow us on Twitter: @msnbc_world

Reuters and The Associated Press contributed to this report.

Source: http://worldnews.msnbc.msn.com/_news/2012/03/10/10630761-dominique-strauss-kahn-bundled-away-from-cambridge-university-protesters

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Saturday, March 10, 2012

Pioneer JV baseball beats Roseville at Raley Field

Behind big hits from Colton Gunter, Anthony Fuentes and Cody Hamer, Pioneer High School's junior varsity baseball team scored six times in the sixth inning and beat Roseville 8-5 at Raley Field on Thursday.

The Patriots entered the bottom of the sixth trailing 3-2 but Gunter's RBI single put them ahead to stay. Fuentes knocked in two runs with a triple and Hamer had an RBI double.

Fuentes also pitched the first four innings. He allowed three hits, three unearned runs and two walks and struck out three. Walker Perry pitched the final three innings. He had eight strikeouts while allowing just one hit.

Anthony Bosser provided the Patriots more offense, going 2 for 4.

Girls soccer

Douglass Middle School 4, Homes 0 -- The host Lions received goals from Maria Gonzalez, Ally Martin, Dhamaris DeLaCruz and Tanya Rodriguez and increased their scoring advantage this season to 13-0 in four games. Helping forge the shutout on defense were Rachel May, Alicia Pimentel and Cassandra Figueroa. Douglass plays Esparto on Tuesday.

Boys soccer

Douglass Middle School 5, Holmes 4 -- After building leads of 3-0 and 5-2, the Lions (3-0) held on to edge the visitors from Davis. Geral Chavez scored twice for Douglass, Michael Lopez and Julian Ramirez had goals in the first half and Jovanni Morales converted a penalty kick for the hosts' final goal. Douglass hosts Esparto Tuesday at 4 p.m.

Source: http://www.dailydemocrat.com/sports/ci_20136891/pioneer-jv-baseball-beats-roseville-at-raley-field?source=rss

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adidas golf shoes News and Society Energy Article ? asics news

The chancellor,air jordan shoe,among offer apt?go green?namely stressing the importance of getting away from the orthodox fossil oils and is pushing Americans apt invest among renewable energy sources such as solar power,adidas golf shoes,oil cells hydroelectric,north face coats for women, and air power. The authority through the gift of contracts,adidas flat shoes,borrow guarantees,asics shoes australia, grants,timberland outlet stores,levy credits and rebates has established one artificially inflated mall as companies seeking entry and sustainability surrounded the choice stamina market The substantial market for alternative stamina is relatively small right instantly partly deserving apt the recession; and even notwithstanding the priced of creation may be decreasing the market has?
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Source: http://asics.lateststyle.org/2012/03/08/adidas-golf-shoes-news-and-society-energy-article/

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Friday, March 9, 2012

Getting The Right Gain Muscle Mass Weight Gain Supplements And ...

New Health And Fitness.Org - Health Information You Can Use

If you want to gain muscle mass weight gain supplements and meal replacements would be the best option. There are endless varieties and the way they work can be quite complex. Although different combinations of ingredients can work differently than they do on their own they may also affect different people in different ways. In the end you can get a good idea of what you need but it might still take a lot of trial and error to figure out what is best for you.

One basic thing that you should be aware of is that everyone reacts to food in different ways because of their own unique internal system. Some of this is indicated by blood type diets but they are not an exact science. One thing that has been confirmed is that we all need different ratios of fats, carbohydrates and protein.

One cannot assume that if you want to build muscle mass that pure protein would be the ideal thing. Some people naturally need high levels of protein and it might be good for them. There are others who need diets that are high in carbohydrates and they would simply perform a lot better if they had enough carbohydrates in their diet. The addition of fat for some people might also be beneficial.

The purpose of gain muscle mass weight gain supplements and meal replacements is either to build muscle mass or to lose weight. If you are going to train hard it is unlikely that you will get enough protein from a normal diet alone. Switching to a diet that is high in protein means that you can almost cut out starches and fats. You will therefore burn more fat than you can store.

This might also be a good strategy if you want to rip your muscles and get very lean. If you just want to bulk up though it might be useful to take a supplement that is not just protein but provides a lot of carbs too. This would allow you to train harder and more often which is also essential to growth.

Other than protein and nutrient supplements it would also be most useful to take creatine monohydrate. This can help you to train harder and it synthesizes protein so that it is more useful to your body. It is naturally found in the body. As phosphocreatine which is stored in the muscles it is used as the energy for muscle contractions. If it is available in larger quantities than you can produce it will give you higher levels of energy and faster recovery.

The most important ingredient for building muscle however is the protein and there are several different types that might be used. The most common are soy and whey protein. There are also very healthy alternative is that are used less often though such as hemp seed protein and a combination of yellow pea and rice extract.

Soy and whey protein are probably the most common but the both have their drawbacks. Whey is sourced from milk so it can be allergenic and soy has phytoestrogen in it which can be problematic in high doses. If you use a combination of the two you can balance out the benefits and side effects. To gain muscle mass weight gain supplements and meal replacements should also contain healthy natural ingredients like hemp seed protein and a combination of rice and yellow pea extract.

Weight gain supplements are useful for individuals who need to bulk up as part of a fitness program. For those who need better nutrition or who want to lose weight, meal replacements are a easy solution.

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Source: http://newhealthandfitness.org/2012/03/08/getting-the-right-gain-muscle-mass-weight-gain-supplements-and-meal-replacements/

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Four Great Good Reasons To Learn To Fly - Leisure Aviation ...

Once the Wright Siblings first required wing the planet transformed where mankind was stuck in 2 dimensions fantasizing of flying within the third dimension. But right after the very first many built their very own powered aircraft and required towards the air.

Very rapidly flying caught the public?s attention, and from 1903 on everybody looks for the sky once they hear an plane overhead. Children built model planes while their parents came to the neighborhood grass strip and viewed pilots remove and land.

Curiosity and imagination were stirred within the youthful and youthful in mind, and shortly aviation required charge in bring innovation and technology around the world.

The Liberty

What attracted mankind right from the start was the liberty they saw wild birds had because they wheeled round the sky, apparently with no care on the planet. The truth is these were hunting, however they looked so peaceful, so elegant and thus free.

For 100s of years prior to the Wright Siblings first flight mankind dreamed of departing the bounds of earth and gravity to soar free on the horizon. It grew to become essential that wealthy people and firms produced awards for most of the firsts in aviation.

To this day many aircraft pilots benefit from the thrill of flying a plane by having an open cockpit, or perhaps a yellow Piper Cub where one can open along side it window and drop the cockpit door to see the new climate while you cruise in a leisurely pace over the countryside.

The Task

In the past of aviation?s pioneers everything would be a challenge, and accidents stated many early aviator?s lives. But, undaunted, they ongoing to climb to their cockpits and challenge the skies.

Until recent time children spent many hrs outdoors making toys from stays and taking advantage of their imagination to produce games and mimic real existence, however nowadays increasingly more they?re glued to the pc screen playing fantasy games.

Understanding how to fly is indeed a challenge, also it takes some serious dedication to accomplish a training course in flying and achieve a pilot?s certificate. Each student pilot is confronted with many challenges, including:

The price of flying training

The vagaries from the weather

Time to review for that written examination

The introduction to aircraft

The supply from the instructor

Most student aircraft pilots take a lot more than the minimum quantity of flying time for you to achieve their goal, but when they are doing they rarely be sorry.

The Careers

For a lot of the non-public pilot certificate is simply a step in order to larger things. Individuals ambitious to fly planes will discover possibilities to complete more than merely pleasure ride round the sky. One of the options for aircraft pilots trying to make a living flying are:

Charter aircraft pilots flying small aircraft transporting people and freight

Crop feather dusters flying low and squirting seed and chemicals

Flight teachers teaching budding aircraft pilots how you can fly

Helicopter aircraft pilots flying medical evacuation helis

Fire control aircraft pilots creating forest fires

Pipeline patrol aircraft pilots checking pipelines and powerlines

Rose bush aircraft pilots delivering necessary supplies to remote areas

Missionary aircraft pilots transporting religion to remote areas

Aerial mapping and photography aircraft pilots

Corporate aircraft pilots flying company professionals

Air travel aircraft pilots flying commercial aircraft

Astronauts grabbing the heavens

They are but a couple of from the varied careers aircraft pilots can seek.

The Pleasure

Anybody that has ever experienced the excitement of controlling a plane all by themselves won?t ever no way. There?s a sophistication, a sense of peace and wellness and a feeling of accomplishment to flying a plane on your own.

As pilot?s gain experience linked with emotions . become one using their machine, feeling its every movement and mood, and delighting within the elegant dance because they learn increasingly more about one another.
Understanding how to fly is just one of individuals stuff that can free you against the worries on the floor, that may raise your spirits and make you one using the sky and also the wild birds from the air.

If you?ve ever considered understanding how to fly go ahead and take leap. See your local airport terminal and discover a teacher and take that first flight. You simply might uncover a peacefulness you won?t ever imagined possible, along with a challenge you simply can?t ignore.

Source: http://leisure-aviation-airplanes.chailit.com/four-great-good-reasons-to-learn-to-fly.html

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Thursday, March 8, 2012

Federal online gaming legislation opposed by NCSL

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In America, the National Conference of State Legislatures (NCSL) bi-partisan non-governmental organisation has penned a letter in opposition to ongoing federal efforts to legalise online poker.

Established in 1975 to serve state legislature members and staff, the NCSL provides research, technical assistance and opportunities for policymakers to exchange ideas on issues and advocate for states? rights in the American federal system.

Hawaii State Senator Carol Fukunaga and Alabama Representative Greg Wren, Co-Chairpersons for the NCSL?s Communications, Financial Services and Interstate Commerce Committee, authored an open letter calling for the legalisation of online poker to be handled at a state level and addressed it to Democratic and Republican members of both the House of Representatives and Senate.

?The NCSL believes the federal government should respect the Justice Department ruling and would oppose any efforts by Congress to preempt state authority over Internet gaming,? read the letter.

?We ask Congress to respect the sovereignty of states and to not consider any legislation that would overturn the Department of Justice?s ruling or to consider any legislation that would regulate gambling at the federal level.

?States have long been able to choose whether or not other forms of gambling should be legal and have been very successful in its regulation. We also ask that the federal government respect the rights of states that choose to prohibit Internet gaming.?

Article source: http://www.igamingbusiness.com/content/federal-online-gaming-legislation-opposed-ncsl

Source: http://lasvegas.im/federal-online-gaming-legislation-opposed-by-ncsl

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Wednesday, March 7, 2012

The Note's Must-Reads for Tuesday, March, 6, 2012

Compiled by ABC News' Jackie Fernandez, Jayce Henderson, and?Amanda VanAllen

SUPER TUESDAY USA Today's Susan page: " Super Tuesday: Will Romney be able to seal the deal?" The Super Tuesday contests are headed toward a split decision, but the biggest election night on the Republican presidential calendar will set the course ahead for the nomination to face President Obama in November - and could mark the moment when Mitt Romney finally emerges as the GOP's all-but-inevitable choice. For the former Massachusetts governor, a victory in the Ohio primary and a show of strength across the country would enable him to argue that he is the only contender with a realistic mathematical chance of claiming the 1,144 delegates needed for nomination. LINK

Bloomberg's Julie Hirschfeld Davis and Lisa Lerer: " Romney Seeks Breakout Super Tuesday" Mitt Romney is reaching for breakout victories today to propel him to a commanding lead in the Republican presidential race, as Rick Santorum presses for enough Super Tuesday support to keep his bid alive and stoke doubts about the front-runner. Polls showed Romney ahead of his competitors among Republican voters nationally, gaining momentum in the swing state of Ohio - one of today's most coveted prizes - and running competitively in Tennessee, a Super Tuesday state the Santorum camp has focused on. LINK

The Wall Street Journal's Patrick O'Connor and Sara Murray: " Ohio and Tennessee Looming Super Large" Three of the four major Republican presidential candidates are on track to claim at least one win in today's 10-state voting. But one candidate, Mitt Romney, has the potential to emerge from the Super Tuesday balloting having transformed from a front-runner into the presumptive leader. The potential for Mr. Romney to enlarge his lead is throwing the spotlight on Ohio and Tennessee. LINK

The New York Times' Jim Rutenberg and Jeff Zeleny: " Romney and Santorum Roll Up Their Sleeves for Blue-Collar Votes" If Mitt Romney defeats Rick Santorum in the bellwether primary here on Tuesday, it will be in no small part because he managed to win over one of the most hotly contested and elusive segments of the electorate: white working-class voters. LINK

The Washington Post's Philip Rucker and Felicia Sonmez: " Super Tuesday: Mitt Romney focuses on economy, while rivals seek openings" As the four remaining Republican presidential candidates head into the most consequential voting day yet, each positioned himself Monday for a breakout moment that so far has proved elusive. LINK

The Washington Times' Seth McLaughlin: " Romney pushes jobs; Santorum lobs attacks" Mitt Romney and Rick Santorum wrapped up their final full day of campaigning here before Tuesday's pivotal Republican presidential primary here, delivering their respective closing arguments as Mr. Santorum's stock dipped in the polls and Mr. Romney brushed off new questions about his support for a federal health care mandate. LINK

The Los Angeles Times' John Hoeffel: " In Ohio, voters share unease about the future" In the fading evening light, Jeff Snider played catch in the middle of the street with his 14-year-old son, the baseball thwacking their mitts. They stepped out of the way and waved when cars passed. The friendly neighborhoods in hilly Oakwood, a picture-perfect suburb nestled against Dayton, belong in a brochure for the American Dream. But the tranquillity hides a churning discontent. LINK

Politico's Darren Samuelsohn: " Green donors bet on Mitt Romney flip-flop" Will Mitt Romney flip-flop on climate change if he's elected president? Some big donors are betting on it. Romney and his super PAC have taken millions from funders with strong green streaks - despite the fact that the former Massachusetts governor has run to the right in the primary, proclaiming doubts about global-warming science and trashing President Barack Obama's greenhouse gas emissions policies. LINK

NEWT GINGRICH ABC News' Elicia Dover: " Gingrich Says Romney Won't Be the Nominee If He Can't Win the South" On the eve of Super Tuesday, Republican presidential candidate Newt Gingrich spent the day flying around Tennessee hoping for a victory in the state as well as in his home state of Georgia. At the last event of the day, Gingrich was asked about Mitt Romney's ability to win southern states. LINK

ABC News' Elicia Dover: " Cain Predicts Gingrich Will Do Better Than Anticipated" After a day of campaigning in Oklahoma, former presidential candidate Herman Cain stopped by Newt Gingrich's last rally of the day in Chattanooga to excite voters to go to the polls Tuesday. In an interview with ABC News, Cain said Gingrich would do better than expected on the day in which Gingrich has been hinging his campaign for the last month. LINK

ABC NEWS VIDEOS "Rick Santorum: 'We're Winning' in Ohio" LINK " Romney at '08 ABC Debate: 'I Like Mandates'" LINK

BOOKMARKS The Note:? LINK The Must-Reads Online:? LINK Top Line Webcast (12noon EST M-F):? LINK ABC News Politics:? LINK The Political Punch (Jake Tapper):? LINK George's Bottom Line (George Stephanopoulos):? LINK Follow ABC News on Twitter:? LINK ABC News Mobile:? LINK ABC News app on your iPhone/iPod Touch/iPad:? LINK

Also Read

Source: http://news.yahoo.com/notes-must-reads-tuesday-march-6-2012-083527405--abc-news.html

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I'm Addicted: Madonna's New Song Leaks


The latest Madonna song leak has hit the Internets.

Just three weeks before the release of the pop icon's new studio album, MDNA, a snippet of one of its tracks, "I'm Addicted," is making the rounds.

With its strong electronic beats and lyrics like "I need to dance," this is a tune that will no doubt get some major play on the radio and at the clubs.

What's it sound like? Hear it for yourself right here:


Madonna - I'm Addicted

Meanwhile, there are rumors running rampant that "I Don't Give A," also from the singer's upcoming disc, is actually a dig at ex-husband Guy Ritchie.

According to the New York Post, the tune includes such lyrics as:

"I tried to be a good girl / I tried to be your wife / Diminished myself / Swallowed my light / I tried to become all / That you expect of me."

"And if it was a failure / I don't give a [bleep]."

Certainly one way to get people talking. MDNA drops March 27. Other notable tracks: "GIRL Gone Wild" (not girls) and "Give Me All Your Luvin."

Source: http://www.thehollywoodgossip.com/2012/03/im-addicted-madonnas-new-song-leaks/

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Tuesday, March 6, 2012

Sun Dome renovations keeping USF sport clubs from practicing ...

[unable to retrieve full-text content]USF's sport clubs such as indoor soccer, club basketball, badminton, men's volleyball and women's volleyball, use the two indoor gyms at the Campus Recreation Center for weekly practices. Intramural events and women's ...

Source: http://digitalbullpen.com/2012/03/05/sun-dome-renovations-keeping-usf-sport-clubs-from-practicing/

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Monday, March 5, 2012

Christmas Party Themes | second floor science

Seeking an interesting twist with a getaway party this season? I?ve got a few of the very original tips lined up: Edward Scissorhands, A Ride Found On The Polar Express, Toy Story 3, Retro Christmas, Peppermint, not to mention 5 more. Check out many of these novel tips for Christmas Theme Parties!

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Peppermint Christmas Party
Hold a peppermint Christmas party not to mention allow the decorations take center stage. Serve peppermint cocktails not to mention peppermint tea, together with peppermint bark not to mention peppermint candies. Scent a home alongside peppermint important oil.

Retro Christmas Party
Play the original boots on Televisions or alternatively computers with all the amount turned down, run a soundtrack alongside records within the aged TV Christmas favorites within the 1970s. Play retro board games. Serve old-school cocktails not to mention comfort food.. The actual blog ?All the time Purchase Dessert? has knocked up a fantastic 1960s Cocktail Party, complete alongside pictures, decor, menu not to mention recipes. Anyone can?t go wrong alongside a pineapple brown sugar glazed ham, devilled eggs, aspic or alternatively jelly salads, ambrosia along with a smoky porcupine cheeseball! Make sure with check it out for tips found on the munchies!!

Gingerbread Home Building Party
Do you really have any kind of bakers or alternatively builders coming over with a house for Christmas? Come with a building party ? a Gingerbread Home Building party! Come with every one of the the pieces prepared ? roofs not to mention walls, possess the icing prepared not to mention possess many candies with decorate alongside. Perhaps you can include a contest into it in which a guests vote found on the right Gingerbread apartment. Allow all the people take home their creations with decorate their apartment alongside. Mothers incredibly might appreciate this you because building a gingerbread apartment is actually some thing we?d every one of the love to do alongside our kids however, don?t possess the time for. Make sure with take many photos, because this party can create a lot of memories.

Santa?s Elves? Business Picnic
Come with a company-style ?picnic? party for every one of the a little elves as soon as you combine gift wrapping or alternatively charity alongside a Christmas party. Come with alternative mommies over with a home for a gift wrapping session alongside a few of the Christmas drinks not to mention sweets. You may also have a children party in which the little ones assemble gift packages not to mention wrap them about donate with those less-fortunate throughout the getaway season.

You may actually do this you alongside just your family. Take the opportunity to wash out closets not to mention donate ?such as new? items with Charity. Polish up overlooked toys, mend dolls not to mention clothes not to mention package them up nicely for Christmas. This takes care of the couple concerns at the exact same time: charity, clutter-busting not to mention good family time.. It also instills a suitable attitude within young minds about reusing items as opposed to consuming more..

Another idea might be to host a Letters with Santa Party alongside food you imagine Santa not to mention Mrs. Claus to consume up at the North Pole.

A Ride Found On The Polar Express
The actual Polar Express is actually a good movie for little guys not to mention little females whom love trains. Incorporate it into a party as soon as you setup model railroads not to mention possess train-inspired Christmas decor. Use ?Polar Express Tickets? for the invitations. In the event that hosting this party, dress up because a train conductor.

Toy Story 3 Greeting Household.
Christmas is actually filled alongside toys should you possess kids within a family. There?s all the time the problem of making space for fresh ones. Toy Story is actually a favorite alongside my kids. They need the Toy Story dolls not to mention I?ve convinced them which you will need to buy 2nd hand versions not to mention rescue a few of the dolls which lost their owners. You have a Toy Story themed party in which your children make certain every one of the their existing toys possess good homes with go with at the finish of the rough day of play plus also attain prepared fresh homes for any kind of toys which may be joining the collection this Christmas. Once again, this may be more suited with a family party, however, it turns an essential de-cluttering not to mention tidying task into a few of the fun play!
A Christmas Carol Dinner
You will like to go the more conventional path not to mention host a Dickensian Christmas party. Come with a conventional Christmas roast with the aged carols not to mention read from Charles Dickens? book or alternatively watch one of several more modern interpretations of the story on DVD.
A Nutcracker Party
Tchaikovskey?s Nutcracker Suite ballet is actually yet another Christmas custom which may go on with inspire a Christmas party. Naturally, you would play the Nutcracker Suite for a soundtrack. Fancy dress costumes might be a good dramatic touch with go and a conventional, but fanciful Christmas meal.
A particular Edward Scissorhands Christmas
The actual Edward Scissorhands soundtrack is incredibly Christmassy though you may certainly not right away think of it. Decorating alongside topiary trees not to mention featuring ice molds within a centerpiece, and also having heart-shaped cookies, might further bring elements together. Perhaps do a few of the crafts of making paper snowflakes or alternatively at least possess a few of the hanging up.
A Whoville Christmas
Your individual Christmas within Whoville may include your Christmas tree light ceremony. Your individual Christmas dinner may be Dr. Seuss whimsical not to mention a decorations will need to be oversized not to mention surreal.. Perhaps possess a limited touches of the grinch alongside little grinch finger or alternatively hand decorations sneaking around with steal some thing. Big hairdos will need to be encouraged from a guests too!

Source: http://secondfloorscience.com/christmas-party-themes/

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What You May Not Know About Associate Degree Online | Obvious ...

Unlike traditional education, online based education is more convenient plus it removes the necessity to move from one place to another as well as trying to maintain various appointments that are as important as the program itself.

The true test of learning is more glaring in online associate degree than in conventional type because coming out with flying colors depends on how each individual pursue their degree. In online settings you don?t have the confinement that each student experience, but freedom which is sometimes what most people need to balance their work life and education and this is what web based education offers. Because most people believe that a bachelor?s degree is the nothing, they have always belittled associate degrees. However the Bureau of labor statistic in the US confirmed that the earning professionals in some key professions today are those with associate degrees.

Perhaps what you want is a technical education. In that case an associate degree is your best bet. However if you want to further your education then you can opt for a bachelor?s degree. But with an associate degree in technical education you don?t need any other thing.

Did you know that web based education is inexpensive when compared to conventional education? In virtually all circumstances online associate program?s costs are lesser than traditional degrees. Take advantage of this and get the certification you need.

With online associate degree no body does the time scheduling for you. You choose when and where to go for classes. Every thing about online education is geared toward making life easy for you. Hence you can conveniently be educated without much stress.

Certainly, an associate degree in culinary arts can avail your numerous chances, if you are interested in culinary arts and want to earn an associate degree in the profession. It can aid you to get hands on experience and provide you with the necessary drive to go ahead and obtain a bachelor?s degree.

Regardless of how much you feel you are aware about Houses for Rent in Raleigh NC and even on Houses for Rent in Raleigh NC, see this awesome site and be educated on truly revealing information

Source: http://obviousarticles.com/reference-education/college/what-you-may-not-know-about-associate-degree-online

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Sunday, March 4, 2012

Can Business VoIP Handle Corporate Communications? | Voip Phone

Voice over Internet Protocol is making a rapid entry into society. Vonage, well known the world over, is at the forefront pushing VoIP as an alternative to traditional home telephone services offered by companies like AT&T and Verizon. There are even devices on the market that will connect your phone to your computer, allowing you to make phone calls via your high-speed Internet connection. With VoIP being touted as the future of communications, can it really make the transition into the corporate environment?

A business communications system is a much larger and more complex entity than a home phone network. Businesses require separate extensions, dial-by-name directories, the ability to transfer calls to other users and numerous other features not needed in a home environment. Up until now, companies needed to purchase their own pricy PBX unit from a telephone hardware vendor and contract with expensive phone system specialists to deploy it and keep it running. Can VoIP providers handle the complexity of all of these extra features?

Business VoIP providers have tailored their product to work just as well as the PBXes offered by the established telephone giants. These VoIP providers offer separate extensions, voicemail features and call transferability, among other things. They even provide for advanced features such as an auto-attendant to answer incoming calls, ACD queues to manage multiple calls at the same time and conference bridges that allow multiple people to talk with each other on the same call. Most providers even have or are developing E911 abilities.

And what?s more, companies that use a hosted business VoIP product for their telephone system enjoy the added advantage of not having to take care of bulky, complicated telecom equipment! The hosted PBX provider handles that- and reputable providers have dedicated and knowledgeable staff members to look after the equipment on a daily basis. By not having a PBX in your office, you can avoid all of the hassle of making sure the system is working, and all of the stress when something goes wrong.

Furthermore, your business can save bundles of money by not having to purchase a PBX, which can cost in the tens of thousands of dollars. By subscribing to a hosted business voip provider, you will only have to pay a low monthly charge (per user or per features enabled, depending on the VoIP provider) to use the service. And there are also savings to be had from the low price per minute for phone calls, averaging 2 to 3 cents per minute. VoIP is incredibly cheaper than traditional telephone calls, essentially due to the fact that VoIP calls ?piggyback? on your company?s Internet connection.

VoIP is well-situated to handle business communications. From the features offered, to the savings incurred, a hosted PBX solution is very appealing for any small to medium-sized company. You trust your high-speed data connection to handle your Internet needs, why not trust it to handle your voice communications as well? The only thing you have to lose is the extra telephone equipment!

OnSIP Hosted PBX is a complete business VoIP service delivered over the Internet. In use by thousands of businesses today, you can sign up and receive a 30 Day FREE trial of the hosted voip service!

Joseph DeBari
Junction Networks

Tags: Business, Communications, Corporate, Handle

Source: http://raterefinancemortgage.net/voipphone/can-business-voip-handle-corporate-communications/

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Saturday, March 3, 2012

PFT: Steelers keep cutting, waive LB Farrior

New Orleans Saints quarterback Drew Brees (below) is sacked in the fourth quarter by San Francisco 49ers outside linebacker Ahmad Brooks during their NFL NFC Divisional playoff football game in San FranciscoReuters

Plenty of you appreciate the fact that we cut through the incomplete and/or misleading reports regarding the value of a given contract and supply the facts.? (Then again, plenty of you don?t, because it?s hardly the most exciting aspect of following the NFL.)

For those of you who don?t like it, we recommend the scroll button.? For those of you who do, it?s time to get out your Rain Man notebook and start writing, because we have the details on linebacker Ahmad Brooks? new six-year deal with the 49ers, courtesy of a league source with knowledge of the contract.

Brooks received $7.5 million to sign, and his $750,000 base salary for 2012 is fully guaranteed.? (Then again, as pointed out last night, the first-year base salary is always as a practical matter guaranteed, because no player gets cut in the first year of a multi-year deal, especially where the base salary represents 10 percent of the signing bonus.)

That?s the extent of the fully guaranteed money in Brooks? contract.

In 2012, Brooks also will receive a per-game active roster bonus of $31,500 ? which for the full season becomes $500,000, and he?s eligible for a workout bonus of $100,000.

For 2013, Brooks has a $4.3 million base salary with an injury guarantee on signing.? As of April 1, 2013, the salary becomes fully guaranteed, if Brooks is still on the roster.

The $4.3 million base salary also contains a so-called de-escalator; it can drop by up to $2.5 million based on Brooks? sack production (or lack thereof) in 2012.? The salary also can increase by up to $500,000. The deal contains for 2013 a $46,875 per-game active roster bonus ($750,000 for the year), and a $100,000 workout bonus.

In 2014, the base salary increases to $5.15 million.? Of that amount, $4.95 million is guaranteed for injury only at signing.? If Brooks is on the roster as of April 1, 2014, the $4.95 million becomes fully guaranteed.? There?s a $2.5 million de-escalator tied to sacks in 2013; the de-escalator for 2014 goes away if the de-escalator applies in 2013.? (Yep, I already have a headache.)? The contract also contains another $46,875 per-game active roster bonus and a $100,000 workout bonus.

For 2015, a $6 million base salary could become partially guaranteed based on a complex formula of ?ifs? and ?ors.?? The main factor for any base salary guarantee in 2015 is that Brooks must be on the roster as of April 1 that year.? There?s also a de-escalator of up to $2.5 million based on 2014 sacks. The $46,875 per-game active roster bonus and the $100,000 workout bonus apply once again.

In 2016, the base salary is $6.5 million, with another de-escalator of up to $2.5 million based on 2015 sacks.? Ditto for the $46,875 per-game active roster bonus and the $100,000 workout bonus.

In 2017, everything is the same, with the base salary moving to $6.95 million.

So it?s a one-year, $8.25 million fully-guaranteed contract with another $9 million or so in injury guarantees and an annual team option to pull the plug and move on.

Source: http://profootballtalk.nbcsports.com/2012/03/02/james-farrior-is-the-next-veteran-steeler-to-go/related/

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Condos-Becoming a Popular Choice in Vacation Stays

If you are looking for top quality condos on the beach for your next vacation plan, check out one of many professionally managed condo rentals from a company proven to provide excellent customer service and great accommodations. You can have something for everyone in your group with features that may include a lighted tennis courts, fully equipped kitchens, saunas, plenty of parking, beautiful balconies, amazing views, and much more.

You will find that there will be no better way to relax than booking a stay at a high quality condo rental. The opportunities of things to do a condo beach rental may seem never-ending when you can enjoy activities such as swimming, fishing, boating, golfing, shopping, fine dining at great eateries, and much more. The small child to the senior citizen will find that a vacation on the beach can provide an enjoyable and relaxing time. You don?t even have to travel far to have a good time as you witness your child building sand castles on the beach, or your parents taking a s bare-foot morning stroll on the cool white sands.

Get all the comforts of home with a vacation stay at condo rentals that provide you an in-unit washer and dryer, paper products, separate bedrooms, linens, color televisions, VCRs and more. You can get the comfort and relaxation you need from all the day?s activities in a one, two, or four-bedroom condos. Burn calories in the daytime or evening with a lighted tennis court or soothe your muscles from your fun packed activities with a time in the sauna or hot tub.

If you want a specific activity to enjoy on your vacation, you can allow expert vacation planner to put a package together for you. You can get choices to include a spa, golf, fishing, romance, or massage vacation package. You can also call and inquire about up-coming events in the surrounding areas so you can plan you vacation according to what activities will be offered.

Choose condos that are managed by a team, which provides excellent customer service. This is the best way to ensure that you will receive the accommodations and deals that is best suited for your needs and interests. You will also be informed of specials and discounts that you are eligible for as well as up-coming deals and specials so you have the opportunity to book your reservation for a future date.

Orange Beach AL condos provide something for everyone. Find out how to make the most of your stay by visiting http://www.brett-robinson.com/

Source: http://www.articlesrx.com/condos-becoming-a-popular-choice-in-vacation-stays/4294

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Friday, March 2, 2012

Home Improvement Projects That Really Pay Off

Many of us watch TV shows and see the amazing transformation of homes and area by professionals and abecedarian do-it-yourselfers. Is it absolutely that easy, we ask ourselves. Could I do it? Where do I begin? What home advance projects will accomplish the better access in the bulk of my home?

What Do You Ambition and What Can You Afford?

There are several acceptable affidavit for absent to redecorate or acclimate your home. If your abode no best reflects your alteration tastes and affairs but you don?t ambition to leave a adorable neighborhood, maybe all you charge to do is accomplish one or two basal changes. Altering a blush scheme, converting a bedchamber into a home office, or advance the kitchen and bath are applied improvements that add artful address and banking value. If a move is in the future, you ambition home advance projects that will accord you the better blast for your blade if it?s time to sell.

Whatever your motives for convalescent your home, accomplish a ambition annual with three categories:
* Have to have
* Would like to have
* Dreams can appear true

When your annual is complete, accede the bulk of money you accept accessible or are able to borrow. Unless you accept absolute funds, accomplish a astute appraisal of what you can afford. Are you planning above renovations that will crave the casework of an artist or a contractor? Will you charge an electrician, a plumber, a carpenter, a painter, or all four? How abundant plan can you do yourself? All these factors have to be taken into annual as you carve down your annual into affordable home advance projects.
How Do You Begin?

Every activity starts with a plan. Itemize aggregate you ambition and anticipate you can afford, and cover a architecture of apartment to be remodeled. If you are traveling to crave able help, now is the time to allocution to contractors, plumbers, and added tradesmen, and to ask for estimates. Comparison-shopping is a must. If you are an able do-it-yourselfer, amount abstracts and accoutrement needed. If you can?t allow to do aggregate on your list, amend your prime needs and accomplish a new plan.
What Projects Are Key?

The best projects for convalescent the bulk of your home are, happily, the a lot of affordable and the easiest to do yourself, even if you are a cool klutz. Ask any absolute acreage abettor for tips on how to adapt a home for resale and you will be told that the abode and backyard should be bankrupt and all ataxia removed. Creating acceptable home accumulator accessories and charwoman and painting the autogenous and exoteric of your house, therefore, are the jobs that top the annual of adorable improvements. The exceptional projects that usually crave able advice are kitchen adjustment aboriginal and bath adjustment second. These accurate upgrades will accommodate the best acknowledgment for your money, and the absolute acreage industry has statistics to prove it.

Source: http://tcm-encyclopaedia.com/home-improvement-projects-that-really-pay-off/

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Video: Romney ?not going there? on Blunt bill

CBT: Top bracket spots up for grabs

CBT bracket projections: There are five teams fighting for two spots on the top line of our bracket. Also, 3 new teams have joined the bracket: Colorado State, South Florida, and VCU. Sliding out: Northwestern, Dayton, and St. Joseph?s.

Source: http://www.msnbc.msn.com/id/3036697/vp/46579422#46579422

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Thursday, March 1, 2012

New iPad rumors: Smaller iPads, 8GB iPad 2 coming later this year (Appolicious)

We?re counting down the days until Apple?s March 7 announcement that will likely mark the launch of the next iteration of its iPad tablet, but the rumors are still pouring in about what we can expect.

According to a pair of stories from Asian publication DigiTimes, Apple has a few options planned for iPad buyers, both those who want to go out for the iPad 3 when it?s announced, and those who would rather opt for cheaper alternatives in the slightly dated iPad 2.

The first of two rumors notes a few things we?ve heard before: namely, that Apple intends to introduce two versions of the iPad 3. Those two iPads will be a 16GB and a 32GB model, according to DigiTimes. This?isn?t really news, given that the iPad 2 comes in multiple sizes (and colors), as does the iPhone. Apple has been offering different versions of the iPad since the beginning, and each one comes with a different price tag to allow users to really get what they want out of their devices.

A cheaper version of last year?s model

What is news is that DigiTimes reports Apple intends to introduce a new version of last year?s tablet, the iPad 2. This one will have a smaller hard drive than the three iPad 2 models currently on the market, coming in at 8GB. That?ll mean the price will be lower as well, because the iPad 3 is likely to hit shelves at the traditional iPad price of $499. That makes the iPad 2 both dated and using a smaller hard drive. And that could mean a pretty significant reduction in price. The report puts it at somewhere between $349 and $399.

Speaking of reductions, there?s a second rumor about iPad iterations from DigiTimes, stating that Apple intends to roll out an iPad model with a 7.85-inch screen. That?s significantly smaller than the 10.1-inch screen the iPad currently sports (and would put the iPad in a size category the late Steve Jobs famously insulted), and would mean another price reduction, down to between $249 and $299, according to the report. DigiTimes says that iPad could be on its way to shelves in the third quarter of 2012.

Finding new iPad customers

All of these rumors make some sense given the changes to the tablet landscape that have occurred in the last few months. Lower-priced iPad 2s and 7.85-inch screens would help Apple to take on the cheaper tablets from Amazon and Barnes & Noble, the Kindle Fire and Nook Tablet, respectively. These made a pretty big impact on the market this holiday season. Both tablets sport bargain prices but some pretty big reductions in power when compared the iPad, but they?re also attacking a segment of the market that no other device maker has really been able to take advantage of up to now. It makes sense that Apple wouldn?t want to cede the cheaper end of the spectrum to Amazon without a fight.

We?ve already heard that Apple plans to roll out an iPad 3 with a Retina display and, potentially, a redesign that tosses the traditional Home button. Those things make sense ? we?ve been hearing about them for months ? but a fleet of devices to fit the lower price ranges makes a lot of sense for Apple. Of course, it?s always best to be a little skeptical of DigiTimes? reports, since they come from anonymous sources who claim to work in Apple?s overseas supply chains. Still, there?s a big portion of the potential tablet market that Apple isn?t reaching, and that Amazon pretty effectively tapped over the holidays. I definitely think it?s possible Apple will offer at least some kind of lower-cost iPad option in 2012.

Source: http://us.rd.yahoo.com/dailynews/rss/applecomputer/*http%3A//us.rd.yahoo.com/dailynews/external/appolicious_rss/rss_appolicious_tc/http___www_appolicious_com_articles11209_new_ipad_rumors_smaller_ipads_8gb_ipad_2_coming_later_this_year/44693355/SIG=13g0cepop/*http%3A//www.appolicious.com/tech/articles/11209-new-ipad-rumors-smaller-ipads-8gb-ipad-2-coming-later-this-year

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Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach

Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach [ Back to EurekAlert! ] Public release date: 29-Feb-2012
[ | E-mail | Share Share ]

Contact: Barbara Yates
barbara@theyatesnetwork.com
781-258-6153
The Yates Network

Research shows for the first time that resident memory T cells prevalent in the skin are more protective in fighting infection than central memory T cells in the bloodstream

BOSTON, MA February 29, 2012 TREM Rx, Inc., a biotechnology company with a proprietary technology platform for novel vaccines delivered to the skin, announced today the results of an in vivo preclinical study that shows, for the first time, that powerful cells of the immune system called TREMs (T Resident Effector Memory cells) prevalent in the skin can mediate a protective immune response that is far stronger than memory T cells that circulate in the bloodstream. The study was published in today's online edition of Nature and was led by TREM Rx scientific founder, Dr. Thomas S. Kupper, the Thomas B. Fitzpatrick Professor of Dermatology at Harvard Medical School, and chair of Dermatology at Brigham and Women's Hospital and the Dana Farber Cancer Institute.

This research and previous work by Dr. Kupper's group demonstrated that a stronger generalized T cell immune response, and in particular a more robust TREM response, can be produced by delivering a viral vaccine vector to the upper skin tissues, as compared to below the skin or into the muscle. This new research reveals why novel vaccines administered to upper layers of the skin in preclinical models have demonstrably better preventative and therapeutic efficacy over conventional vaccine injection into the muscles or bloodstream. TREM Rx has exclusive rights to this vaccine-relevant intellectual property as the basis for the company's proprietary technology platform for developing novel vaccines.

"Conventional vaccines are typically focused on optimizing the B cell arm of the immune system to create disease-fighting antibodies. In contrast, this study shows that a more effective path to immunity may be to engage this newly discovered part of the T cell arm of the immune system through a population of powerful immune cells that we now know reside in the skin, lung, gut, and other epithelial tissues," said Thomas S. Kupper, MD, senior author of the Nature paper.

"Putting this research in historical context, it helps explain the uniquely powerful efficacy of the first successful vaccine developed for smallpox by Jenner in 1796," said Kupper. "Syringes had not yet been invented, so Jenner administered the first vaccine by disrupting the upper layers of skin with a specialized needle, a process similar to how the vaccinia virus was delivered in our study. It is worth remembering that the smallpox vaccine remains the most effective vaccine in the history of medicine, resulting in the elimination of smallpox in human populations."

In the preclinical study in Nature, vaccinia virus delivered to the skin was found to rapidly recruit viral-specific T cells, called TREMs (T Resident Effector Memory cells), not just to the infected site, but also to all areas of the skin. These TREMs remained in skin, and provided rapid and effective protection against a second infection from the same virus. While skin was used as a model system in the study, the results are relevant to epithelial cells in the lungs, GI tract, and other epithelial tissues that are sites of viral entry to the body.

The findings of this study challenge immunological dogma by suggesting that the most important elements of T cell memory and immunity to infectious diseases may reside in skin and other epithelial tissues mediated by TREMs, rather than by circulating T or B cells in the blood. With regard to the impact on vaccine design and delivery, the study suggests that vaccines to generate TREM can be optimized by delivery through epithelial tissues, for a potentially more effective immune response than is achieved with conventional vaccine injection.

"This groundbreaking research provides a major opportunity to develop a new class of vaccines with improved preventative and therapeutic efficacy that can potentially have a major impact on human health," said Eric Stromquist, president of TREM Rx. "We are committed to translating this new understanding of protective immunity to the design of novel vaccines for a wide range of applications, including important infectious diseases and cancers."

###

About TREM Rx

TREM Rx is a biotechnology company with a proprietary technology platform to create and administer highly effective vaccines that are delivered to the upper layers of skin, rather than to deeper layers of skin, subcutaneous tissue, or muscle as conventional vaccines are delivered. The company's novel approach is based on the discoveries of its scientific founder and his colleagues, who found that powerful cells of the immune system called TREMs (T Resident Effector Memory cells) reside in skin and other epithelial tissues, and can mediate a dramatically strong and effective memory immune response against pathogens. In addition to an innovative route of administration into the skin, TREM Rx vaccines are created using safer engineered replication-deficient viruses that are effective at generating TREMs in epithelial tissues. The company is pursuing the application of its novel vaccines to a wide range of diseases, including important infectious diseases and cancers with unmet medical needs.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach [ Back to EurekAlert! ] Public release date: 29-Feb-2012
[ | E-mail | Share Share ]

Contact: Barbara Yates
barbara@theyatesnetwork.com
781-258-6153
The Yates Network

Research shows for the first time that resident memory T cells prevalent in the skin are more protective in fighting infection than central memory T cells in the bloodstream

BOSTON, MA February 29, 2012 TREM Rx, Inc., a biotechnology company with a proprietary technology platform for novel vaccines delivered to the skin, announced today the results of an in vivo preclinical study that shows, for the first time, that powerful cells of the immune system called TREMs (T Resident Effector Memory cells) prevalent in the skin can mediate a protective immune response that is far stronger than memory T cells that circulate in the bloodstream. The study was published in today's online edition of Nature and was led by TREM Rx scientific founder, Dr. Thomas S. Kupper, the Thomas B. Fitzpatrick Professor of Dermatology at Harvard Medical School, and chair of Dermatology at Brigham and Women's Hospital and the Dana Farber Cancer Institute.

This research and previous work by Dr. Kupper's group demonstrated that a stronger generalized T cell immune response, and in particular a more robust TREM response, can be produced by delivering a viral vaccine vector to the upper skin tissues, as compared to below the skin or into the muscle. This new research reveals why novel vaccines administered to upper layers of the skin in preclinical models have demonstrably better preventative and therapeutic efficacy over conventional vaccine injection into the muscles or bloodstream. TREM Rx has exclusive rights to this vaccine-relevant intellectual property as the basis for the company's proprietary technology platform for developing novel vaccines.

"Conventional vaccines are typically focused on optimizing the B cell arm of the immune system to create disease-fighting antibodies. In contrast, this study shows that a more effective path to immunity may be to engage this newly discovered part of the T cell arm of the immune system through a population of powerful immune cells that we now know reside in the skin, lung, gut, and other epithelial tissues," said Thomas S. Kupper, MD, senior author of the Nature paper.

"Putting this research in historical context, it helps explain the uniquely powerful efficacy of the first successful vaccine developed for smallpox by Jenner in 1796," said Kupper. "Syringes had not yet been invented, so Jenner administered the first vaccine by disrupting the upper layers of skin with a specialized needle, a process similar to how the vaccinia virus was delivered in our study. It is worth remembering that the smallpox vaccine remains the most effective vaccine in the history of medicine, resulting in the elimination of smallpox in human populations."

In the preclinical study in Nature, vaccinia virus delivered to the skin was found to rapidly recruit viral-specific T cells, called TREMs (T Resident Effector Memory cells), not just to the infected site, but also to all areas of the skin. These TREMs remained in skin, and provided rapid and effective protection against a second infection from the same virus. While skin was used as a model system in the study, the results are relevant to epithelial cells in the lungs, GI tract, and other epithelial tissues that are sites of viral entry to the body.

The findings of this study challenge immunological dogma by suggesting that the most important elements of T cell memory and immunity to infectious diseases may reside in skin and other epithelial tissues mediated by TREMs, rather than by circulating T or B cells in the blood. With regard to the impact on vaccine design and delivery, the study suggests that vaccines to generate TREM can be optimized by delivery through epithelial tissues, for a potentially more effective immune response than is achieved with conventional vaccine injection.

"This groundbreaking research provides a major opportunity to develop a new class of vaccines with improved preventative and therapeutic efficacy that can potentially have a major impact on human health," said Eric Stromquist, president of TREM Rx. "We are committed to translating this new understanding of protective immunity to the design of novel vaccines for a wide range of applications, including important infectious diseases and cancers."

###

About TREM Rx

TREM Rx is a biotechnology company with a proprietary technology platform to create and administer highly effective vaccines that are delivered to the upper layers of skin, rather than to deeper layers of skin, subcutaneous tissue, or muscle as conventional vaccines are delivered. The company's novel approach is based on the discoveries of its scientific founder and his colleagues, who found that powerful cells of the immune system called TREMs (T Resident Effector Memory cells) reside in skin and other epithelial tissues, and can mediate a dramatically strong and effective memory immune response against pathogens. In addition to an innovative route of administration into the skin, TREM Rx vaccines are created using safer engineered replication-deficient viruses that are effective at generating TREMs in epithelial tissues. The company is pursuing the application of its novel vaccines to a wide range of diseases, including important infectious diseases and cancers with unmet medical needs.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-02/tyn-din022612.php

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